How Tetrahydrogestrinone was discoveredTetrahydrogestrinone (THG) is often referred to as “The Clear”. It is an anabolic steroid developed by Patrick Arnold for Bay Area Laboratory Cooperative (BALCO), an American nutritional supplement company. The drug has great affinity to the androgen and progesterone receptors but not the estrogen receptor.

Side effects of THG include infertility in both genders; acne; hirsutism; and sometimes, immunosuppression.

Before its discovery, it is considered the drug of choice by many athletes due to its “invisible” effects in the world of sports. Some of the athletes who admitted to using it were Marion Jones, the sprinter and British athlete Dwain Chambers.

It was first discovered in June 2003, when a spent syringe containing undetectable anabolic steroid was anonymously provided to the United States Anti-doping Agency (USADA). The research team was led by Dr. Don Catlin, MD, the then-director of the UCLA Olympic Analytical Lab.

Dr. Catlin and associates were able to synthesize a compound, which matched the unknown substance in the syringe. They then proceed to develop a new detection test for this particular compound, which they named as tetrahydrogestrinone.

At present, THG is detectable in the urine after both intravenous and intramuscular administration. Dr. Catlin was later named as Sportsman of the Year by the Chicago tribune.

From The Medical News:

In June 2003, a spent syringe having allegedly contained an undetectable anabolic steroid was anonymously provided to the United States Anti-Doping Agency (USADA), and the contents delivered to the research team in Los Angeles. The researchers, led by Don Catlin, detected an unfamiliar substance and deduced its chemical formula. They were then able to synthesize a compound with this formula, which they named tetrahydrogestrinone (THG) and which matched the unknown substance in the syringe.


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