Thursday 16, Jul 2009
New class of Anti-inflammatory Drugs defined
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Non-steroid anti-rheumatic drugs (NSAR) such as acetylsalicylic acid (aspirin) have always been common and popular choices when it comes to treating pain, fever, and inflammation. But a recent study revealed that these drugs would not have passed even the clinical trial stage because of the risk factor and side-effects.
In order to find an effective alternative, a new approach has been developed using chemical substances belonging to the dual mPGES-1/5-LO-Inhibitors at the Manfred Schubert-Zsilavecz’s laboratory at the Goethe University.
From News-Medical.Net:
Aspirin and the related NSAR drugs act on the arachidonic acid biosynthesis cascade, which plays a central role in the onset of pain and inflammation. They thus prevent the synthesis of specific prostaglandins, which are essential for vital bodily functions. When the drugs are taken over a long period of time, the unselective inhibition of this essential pathway may result in unwanted side effects on the gastrointestinal tract and the cardiovascular system. As Schubert-Zsilavecz explains: “By comparison, our class of drugs/substances acts on a later stage in the arachidonate cascade, and is more selective. We therefore can expect it to have considerably fewer side effects.”
A further advantage of this new class of drugs is that they not only specifically target the biosynthesis of prostaglandin, but also of leukotrienes, which are metabolites in the second important branch of the arachidonate cascade and play a central role in allergic and inflammatory reactions. This double attack promises more effective results for these new substances.
According to Gerd Geisslinger, Speaker of the LiFF-Initiative and President of the Center for Drug Research, Development and Safety (ZAFES), this is one of the most important successes of their Lipid Signaling Research Centre.
The new class of drugs specifically targets the biosynthesis of prostaglandin and leukotrienes besides playing a pivotal role in inflammatory and allergic reactions.
Tags: acetylsalicylic acid, aspirin, leukotrienes, non steroid anti rheumatic drugs, NSAR drugs, prostaglandin, steroid
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